Micronised PEA, FORTIGEL® collagen, Boswellia and vitamins C and D for joint well-being
Fulcro is a food supplement in a liquid emulsion, formulated to support joint well-being, with particular attention to cartilage, bone structure and joint comfort.
The formulation combines micronised PEA (palmitoylethanolamide), FORTIGEL® collagen peptides, Boswellia serrata, vitamin C and vitamin D3, bringing together ingredients selected for their different functional properties.
Fulcro stands out for its ready-to-drink format in 10 ml single-dose sticks, allowing convenient intake without dilution.
Joint well-being: the role of cartilage and connective tissues
Joints allow movement through the interaction of cartilage, bones, ligaments and other supporting tissues.
Articular cartilage helps distribute loads and reduce friction between bone surfaces. With ageing and repeated stress, joint structures may undergo changes associated with stiffness and reduced mobility.
Maintaining the normal structure of cartilage and bones is therefore an important aspect of musculoskeletal well-being.
FORTIGEL® collagen: support for cartilage structure
Fulcro contains 5 g of FORTIGEL® collagen peptides per stick, a raw material characterised by specific collagen peptides.
Collagen is a key structural component of the extracellular matrix of cartilage, helping provide strength and organisation.
Collagen peptide supplementation has been studied in relation to joint well-being, with particular attention to the function of joints exposed to stress.
FORTIGEL® is a distinctive feature of the formulation, through the use of branded collagen peptides.
Micronised PEA and Boswellia: complementary ingredients
Palmitoylethanolamide (PEA) is an endogenous lipid compound belonging to the N-acylethanolamine family, studied for its involvement in mechanisms that modulate the neuroinflammatory response.
Fulcro provides 600 mg of micronised PEA per stick. Micronisation is a technology used to reduce particle size, a feature of interest in the development of oral formulations.
Boswellia serrata, included at 100 mg per stick, is a plant traditionally used in formulations dedicated to joint function.
The combination of PEA and Boswellia completes the profile of Fulcro, complementing collagen peptides with ingredients studied in relation to musculoskeletal comfort.
Vitamins C and D: collagen, cartilage and bones
The formulation is enriched with 100 mg of vitamin C and 25 µg of vitamin D3 per stick.
Vitamin C contributes to normal collagen formation for the normal function of cartilage and bones. It also contributes to the protection of cells from oxidative stress and to the reduction of tiredness and fatigue.
Vitamin D contributes to the maintenance of normal bones and normal muscle function, completing the nutritional profile of the formulation.
Scientific evidence on PEA and Boswellia for joint well-being
Scientific literature has explored the role of PEA and Boswellia extracts in musculoskeletal comfort.
A systematic review and meta-analysis published in Nutrients in 2023 analysed 11 double-blind randomised clinical trials involving a total of 774 participants, finding a significant reduction in pain intensity in the PEA-treated groups compared with controls.
A meta-analysis published in BMC Complementary Medicine and Therapies in 2020 assessed 7 randomised clinical trials involving 545 patients with osteoarthritis. The results showed improvements in pain, stiffness and joint function with certain Boswellia extracts compared with control groups.
Fulcro for B2B and private label projects
Are you looking for a food supplement for joint well-being that is ready for market or available for private label development?
We are certified manufacturers of medical devices, food supplements and cosmetics, developing innovative formulations for the well-being of joints, cartilage and the musculoskeletal system. Fulcro is available for B2B and private label projects, with comprehensive formulation, regulatory and manufacturing support.
Contact us for more information about the product and to explore opportunities for collaboration.
References
1. Lang-Illievich K, et al. Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2023;15(6):1350. DOI: 10.3390/nu15061350.
2. Yu G, et al. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complementary Medicine and Therapies. 2020;20:225. DOI: 10.1186/s12906-020-02985-6.
