{"id":9090,"date":"2026-09-16T07:00:00","date_gmt":"2026-09-16T06:00:00","guid":{"rendered":"https:\/\/www.pjpharma.it\/?p=9090"},"modified":"2026-09-14T16:39:21","modified_gmt":"2026-09-14T15:39:21","slug":"kerafol-keratolytic-cream-for-hyperkeratosis","status":"publish","type":"post","link":"https:\/\/www.pjpharma.it\/en\/kerafol-keratolytic-cream-for-hyperkeratosis\/","title":{"rendered":"Kerafol: Keratolytic Cream for Hyperkeratosis"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">High-concentration urea, salicylic acid and lactic acid to smooth the skin and support renewal of the stratum corneum<br><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Hyperkeratosis is a thickening of the stratum corneum, the outermost layer of the epidermis. It can appear as rough skin, flaking, calluses and localized thickened areas, especially in zones subject to pressure or friction, such as the feet, heels, hands and elbows.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In these cases, a keratolytic formulation helps remove excess surface cells and improve skin texture. High-concentration urea is a particularly interesting ingredient for this type of application, thanks to its ability to combine exfoliating action with moisturizing properties.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/www.pjpharma.it\/en\/kerafol-2\/\">Kerafol<\/a><\/strong> fits into this context with a concentrated formula, designed for the cosmetic care of thickened areas and to help achieve visibly smoother skin.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Urea 50%: keratolytic and moisturizing action<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Urea is a component naturally present in the <strong>Natural Moisturizing Factor (NMF)<\/strong>, the complex of substances that helps maintain hydration of the stratum corneum. Its action varies depending on concentration: at low percentages the humectant effect prevails, while at high concentrations its keratolytic activity becomes particularly significant.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"wp-block-paragraph\">In <strong><a href=\"https:\/\/www.pjpharma.it\/en\/kerafol-2\/\">Kerafol<\/a><\/strong>, 50% urea helps soften the thickened stratum corneum and promotes the shedding of surface cells, while at the same time improving the skin&#8217;s ability to retain water. This dual action makes the formulation particularly suitable for the care of calluses, roughness and localized hyperkeratosis.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.pjpharma.it\/en\/kerafol-2\/\"><img fetchpriority=\"high\" decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/www.pjpharma.it\/wp-content\/uploads\/2026\/09\/kerafol.png\" alt=\"\" class=\"wp-image-9084\" srcset=\"https:\/\/www.pjpharma.it\/wp-content\/uploads\/2026\/09\/kerafol.png 500w, https:\/\/www.pjpharma.it\/wp-content\/uploads\/2026\/09\/kerafol-300x300.png 300w, https:\/\/www.pjpharma.it\/wp-content\/uploads\/2026\/09\/kerafol-150x150.png 150w, https:\/\/www.pjpharma.it\/wp-content\/uploads\/2026\/09\/kerafol-100x100.png 100w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><\/figure>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Salicylic acid, lactic acid and glycerin: a complementary combination<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Urea&#8217;s action is complemented by three ingredients with complementary functions:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Salicylic acid 1.9%:<\/strong> promotes exfoliation of the stratum corneum and helps reduce the buildup of surface cells.<\/li>\n\n\n\n<li><strong>Lactic acid 0.4%:<\/strong> takes part in the surface renewal process and helps improve skin smoothness.<\/li>\n\n\n\n<li><strong>Glycerin:<\/strong> acts as a humectant, helping to maintain skin hydration and softness.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The combination of keratolytic and humectant agents makes it possible to address roughness and dryness at the same time, enhancing the skin-smoothing profile of the cream.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Scientific evidence on high-concentration urea<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The role of urea in dermatological formulations is documented in numerous scientific publications. A review published in 2020 in the <em>International Journal of Clinical Practice<\/em> examined the clinical evidence on high-concentration urea, highlighting its keratolytic, moisturizing and emollient properties and its use in conditions characterized by hyperkeratosis, including calluses and keratodermas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A subsequent review published in 2021 in <em>Dermatology and Therapy<\/em> confirmed the role of urea in maintaining hydration and skin barrier function, as well as its keratolytic activity in high-concentration formulations.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-center\">Kerafol for B2B and private label projects<\/h3>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Looking for a market-ready keratolytic cream with high-concentration urea, or one that can be developed as a private label product?<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">We are certified manufacturers of medical devices, food supplements and cosmetics, and we develop formulations for skin wellness and care. <strong><a href=\"https:\/\/www.pjpharma.it\/en\/kerafol-2\/\">Kerafol<\/a> is available for B2B and private label projects<\/strong>, with full formulation, regulatory and production support.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Contact us for more information about the product and to explore collaboration opportunities.<\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns9083_1cbb67-65{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns9083_1cbb67-65 .kt-button{font-weight:normal;font-style:normal;}.kt-btns9083_1cbb67-65 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns9083_1cbb67-65 .kt-btn-wrap-0 .kt-button{color:#555555;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns9083_1cbb67-65 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns9083_1cbb67-65 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns9083_1cbb67-65 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns9083_1cbb67-65 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns9083_1cbb67-65 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns9083_1cbb67-65\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn9083_56e249-a1.kb-button{width:initial;}<\/style><a class=\"kb-button kt-button button kb-btn9083_56e249-a1 kt-btn-size-standard kt-btn-width-type-auto kb-btn-global-fill kt-btn-has-text-true kt-btn-has-svg-false wp-block-kadence-singlebtn\" href=\"https:\/\/www.pjpharma.it\/contatti-pj-pharma-sede-operativa\/\"><span class=\"kt-btn-inner-text\">Contact us<\/span><\/a><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">References<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Starace M, et al. <em>Clinical evidences of urea at high concentration on skin and annexes<\/em>. International Journal of Clinical Practice. 2020.<\/li>\n\n\n\n<li>Piquero-Casals J, et al. <em>Urea in Dermatology: A Review of its Emollient, Moisturizing, Keratolytic, Skin Barrier Enhancing and Antimicrobial Properties<\/em>. Dermatology and Therapy. 2021;11:1905\u20131915. DOI: 10.1007\/s13555-021-00611-y.<\/li>\n\n\n\n<li>Celleno L. <em>Topical urea in skincare: A review<\/em>. Dermatologic Therapy. 2018;31(6):e12690. DOI: 10.1111\/dth.12690.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kerafol combines 50% urea with salicylic acid, lactic acid and glycerin in a keratolytic cream designed for hyperkeratosis, calluses and rough, thickened skin. Available for B2B and private label projects.<\/p>\n","protected":false},"author":2,"featured_media":9089,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[410],"tags":[549,2962,2955,548,565,2961],"class_list":["post-9090","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","tag-dermocosmetics","tag-hyperkeratosis","tag-kerafol","tag-medical-devices","tag-private-label","tag-urea"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Kerafol: Keratolytic Cream for Hyperkeratosis - PJ PHARMA<\/title>\n<meta name=\"description\" content=\"Kerafol: a keratolytic cream with 50% urea, salicylic and lactic acid for hyperkeratosis and calluses. 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