The formulation combines magnesium alginate, sodium alginate, low molecular weight hyaluronic acid, simethicone, and myrrh extract. <\/strong>The barrier action of the alginates works alongside protective, soothing support for the gastroesophageal mucosa and the action of simethicone on gas-related discomfort. The product is available in a bottle with a measuring cup and dosing syringe.<\/p>\n\n\n\n Gastroesophageal reflux occurs when stomach contents rise into the esophagus, causing symptoms such as retrosternal burning, acid regurgitation, and heartburn. When episodes are frequent or persistent, they can affect daily wellbeing and require medical evaluation. Management of gastroesophageal reflux disease (GERD) depends on symptom severity and may include lifestyle changes, pharmacological treatments, and mechanically acting devices.<\/p>\n\n\n\n Repeated contact with gastric content can irritate the esophageal mucosa and contribute to burning, regurgitation, and retrosternal discomfort. In some patients, extra-esophageal symptoms such as laryngeal irritation may also occur, although these should be properly assessed diagnostically.<\/p>\n\n\n\n Alginates represent a mechanical approach to reflux control: on contact with the gastric environment, they form a gel-like structure that helps hinder the rise of acidic content. This mechanism is distinct from acid secretion suppression and can be useful in the symptomatic control of GERD.<\/p>\n\n\n\n The Reflucalm Plus<\/a><\/strong> formulation combines components with complementary functions:<\/p>\n\n\n\n The composition also includes gum arabic, xanthan gum, and guar seed flour.<\/p>\n<\/div>\n\n\n\n The multi-action system of Reflucalm Plus<\/a><\/strong> is designed to address different aspects of the symptoms. Alginates help create a physical barrier, while hyaluronic acid supports hydration and protection of the gastroesophageal mucosa. Simethicone acts on gas-related discomfort, and myrrh contributes to the comfort of irritated mucosa.<\/p>\n\n\n\n This combination makes the product suitable for:<\/p>\n\n\n\n Alginate-based formulations have been studied for the treatment of gastroesophageal reflux symptoms. A systematic review and meta-analysis published in Diseases of the Esophagus<\/em> analyzed the results of several clinical studies, finding that alginates may offer a benefit in symptom control compared with placebo or antacids. The results support their use as a mechanically acting approach, although there are differences between the formulations and studies considered.<\/p>\n\n\n\n The mechanism of action of alginates has also been investigated through studies evaluating their ability to form a floating barrier on gastric content. This structure helps limit the rise of acidic material toward the esophagus, acting differently from drugs that reduce acid secretion. The barrier formed by alginates therefore helps reduce contact between acidic gastric content and the esophageal mucosa, supporting control of reflux symptoms.<\/strong><\/p>\n\n\n\n PJ Pharma develops and offers solutions for the gastroenterology sector, with formulation, regulatory, and manufacturing support. Reflucalm Plus<\/a> is available for B2B and private label projects. Contact us for technical and commercial information and to explore product development opportunities.<\/strong> <\/p>\n\n\n\n The mechanism of action of alginates has also been investigated through studies evaluating their ability to form a floating barrier on gastric content. This structure helps limit the rise of acidic material toward the esophagus, acting differently from drugs that reduce acid secretion. The barrier formed by alginates therefore helps reduce contact between acidic gastric content and the esophageal mucosa, supporting control of reflux symptoms.<\/strong><\/p>\n\n\n\n We are certified manufacturers of medical devices, food supplements, and cosmetics, and we develop innovative formulations for gastrointestinal wellbeing. Reflucalm Plus<\/a><\/strong> is available for B2B and private label projects, with complete formulation, regulatory, and manufacturing support.<\/p>\n\n\n\n Contact us for more information about the product and to explore collaboration opportunities.<\/strong><\/p>\n\n\nGastroesophageal reflux: symptoms and mucosal protection<\/h2>\n\n\n\n
Alginates, hyaluronic acid, and simethicone: the Reflucalm Plus formulation<\/h2>\n\n\n\n
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<\/a><\/figure>\n<\/div>\n<\/div>\n\n\n\nBarrier action and support against reflux-related discomfort<\/h2>\n\n\n\n
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Scientific evidence on alginates and mucosal protection<\/h2>\n\n\n\n
Looking for a ready-to-market oral gel for gastroesophageal reflux, or one that can be developed as private label?<\/h4>\n\n\n\n