{"id":7564,"date":"2026-03-30T14:33:44","date_gmt":"2026-03-30T13:33:44","guid":{"rendered":"https:\/\/www.pjpharma.it\/?p=7564"},"modified":"2026-04-10T14:48:29","modified_gmt":"2026-04-10T13:48:29","slug":"reflusod-in-adult-gastroesophageal-reflux","status":"publish","type":"post","link":"https:\/\/www.pjpharma.it\/en\/reflusod-in-adult-gastroesophageal-reflux\/","title":{"rendered":"Reflusod in adult gastroesophageal reflux"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>Clinical study on Reflusod in adults: significant improvement in GERD symptoms<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Gastroesophageal reflux disease (GERD)<\/strong>&nbsp;is one of the most widespread digestive conditions in the adult population. Symptoms such as&nbsp;<strong>retrosternal burning, acid regurgitation, dysphagia, abdominal bloating, and sleep disturbances<\/strong>&nbsp;can significantly impair quality of life and work performance.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gastroesophageal reflux in adults is internationally recognized as a condition with a&nbsp;<strong>high impact on quality of life<\/strong>. The guidelines of the&nbsp;<a href=\"https:\/\/www.worldgastroenterology.org\/guidelines\/gastroesophageal-reflux-disease\" target=\"_blank\" rel=\"noreferrer noopener\">World Gastroenterology Organisation (WGO)<\/a>&nbsp;emphasize the importance of proper symptom evaluation and the use of&nbsp;<strong>validated tools<\/strong>&nbsp;to monitor treatment effectiveness.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The&nbsp;<a href=\"https:\/\/www.msdmanuals.com\/professional\/gastrointestinal-disorders\/esophageal-and-swallowing-disorders\/gastroesophageal-reflux-disease-gerd\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>MSD Manual \u2013 Professional Version<\/strong><\/a>&nbsp;also highlights how GERD can present in&nbsp;<strong>erosive and non-erosive forms (NERD)<\/strong>, with symptoms such as retrosternal burning, regurgitation, dysphagia, and sleep disturbances, which can significantly affect the daily well-being of adult patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to international scientific literature, GERD can manifest in different clinical forms:&nbsp;<strong>NERD (Non-Erosive Reflux Disease), functional heartburn, hypersensitive esophagus to acid and non-acid reflux<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this context comes&nbsp;<a href=\"https:\/\/www.pjpharma.it\/en\/product\/reflusod\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Reflusod (FT.CE.107.H)<\/strong><\/a>, an oral CE medical device developed by Gruppo FarmaImpresa for the treatment of symptoms related to gastroesophageal reflux in adults.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The reported data refer to an&nbsp;<strong>observational clinical study conducted by Gruppo Farmaimpresa in May 2025<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udca1 To explore the regulatory and clinical context of GERD devices, also read the article on how<a href=\"https:\/\/farmaimpresa.com\/en\/gfi-extends-mdd-certificate-for-gerd-devices\/\" target=\"_blank\" rel=\"noreferrer noopener\">&nbsp;GFI has extended certifications for GERD medical devices,<\/a>&nbsp;ensuring the&nbsp;<strong>regulatory reliability<\/strong>&nbsp;of solutions such as Reflusod.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Clinical study on Reflusod in adults: methodology<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The prospective observational clinical study involved:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>20 adult patients<\/strong><\/li>\n\n\n\n<li><strong>Average age: 58.45 years<\/strong><\/li>\n\n\n\n<li><strong>Treatment duration: 4 weeks<\/strong><\/li>\n\n\n\n<li><strong>Assessment at baseline (T0) and post-treatment (T1)<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Assessment tool: GERD-HRQL<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Efficacy was measured using the&nbsp;<strong>GERD-HRQL (Gastroesophageal Reflux Disease \u2013 Health Related Quality of Life)<\/strong>, an internationally validated questionnaire to assess:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Intensity of heartburn<\/li>\n\n\n\n<li>Regurgitation<\/li>\n\n\n\n<li>Heartburn in supine position<\/li>\n\n\n\n<li>Impact on diet<\/li>\n\n\n\n<li>Night awakenings<\/li>\n\n\n\n<li>Dysphagia<\/li>\n\n\n\n<li>Abdominal bloating<\/li>\n\n\n\n<li>Patient satisfaction<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Clinical results in adults: significant reduction in GERD-HRQL score<\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><a href=\"https:\/\/www.pjpharma.it\/wp-content\/uploads\/2026\/04\/download-16.webp\"><img decoding=\"async\" src=\"https:\/\/www.pjpharma.it\/wp-content\/uploads\/2026\/04\/download-16.webp\" alt=\"\" class=\"wp-image-7562\" style=\"width:653px;height:auto\"\/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">As illustrated in the graph of overall GERD-HRQL scores, the mean value&nbsp;<strong>dropped dramatically from 22.90 (T0) to 6.55 (T1)<\/strong>&nbsp;after just 4 weeks of treatment, with extremely strong statistical significance (<strong>p &lt; 0.001<\/strong>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This improvement is not only numerical:&nbsp;<strong>100% of patients achieved at least a 50% reduction in score<\/strong>, reaching a threshold below 16 points which, according to the reference scientific literature, indicates&nbsp;<strong>clinical remission of GERD<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Analyzing individual parameters, a&nbsp;<strong>near-complete resolution of the most disabling symptoms<\/strong>&nbsp;is observed, such as nocturnal heartburn and postprandial regurgitation, restoring patients to&nbsp;<strong>optimal quality of life and lasting digestive comfort<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Mechanism of action<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Reflusod acts by forming a&nbsp;<strong>protective gastroesophageal mechanical barrier<\/strong>, capable of:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Limiting acid contact with the mucosa<\/li>\n\n\n\n<li>Reducing esophageal irritation<\/li>\n\n\n\n<li>Decreasing the frequency of regurgitation<\/li>\n\n\n\n<li>Improving digestive comfort<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">It does not interfere with gastric physiology but exerts a&nbsp;<strong>local protective action<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Who is Reflusod indicated for?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A&nbsp;<strong>clinically validated solution<\/strong>&nbsp;for:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Gastroesophageal reflux disease (GERD)<\/li>\n\n\n\n<li>NERD<\/li>\n\n\n\n<li>Functional heartburn<\/li>\n\n\n\n<li>Hypersensitive esophagus to acid and non-acid reflux<\/li>\n\n\n\n<li>Persistent uncontrolled symptoms<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Suitable for&nbsp;<strong>gastroenterological settings and integrated management of adult patients<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Why choose Reflusod?<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Prospective clinical study in adults<\/strong><\/li>\n\n\n\n<li><strong>71% reduction in GERD-HRQL score<\/strong><\/li>\n\n\n\n<li><strong>100% of patients with \u226550% improvement<\/strong><\/li>\n\n\n\n<li><strong>Assessment using an internationally validated questionnaire<\/strong><\/li>\n<\/ul>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong>Looking for a ready-to-market B2B or private label solution?<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">We are certified manufacturers of&nbsp;<strong>medical devices, food supplements, and cosmetics<\/strong>. Reflusod (FT.CE.107.H) is ready for market launch or available in&nbsp;<strong>private label format<\/strong>, with full&nbsp;<strong>regulatory and clinical support<\/strong>.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"mailto:info@farmaimpresa.it\"><strong>Contact Us<\/strong><\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A clinical trial conducted on adults with gastroesophageal reflux disease (GERD) demonstrated that Reflusod, an oral medical device, can significantly reduce symptoms after just 4 weeks of treatment. The GERD-HRQL score decreased by 71%, with 100% of patients achieving an improvement of at least 50%.<\/p>\n","protected":false},"author":2,"featured_media":7565,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[412],"tags":[2238,2118,2143,2237,2239,2240,2054,2242,2125,2241,2144],"class_list":["post-7564","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-studies","tag-score-reduction","tag-clinical-support","tag-gastroesophageal-reflux-disease","tag-gerd-hrql-score","tag-gerd-symptoms","tag-non-acid-reflux","tag-observational-clinical-study","tag-prospective-clinical-study","tag-reflusso-gastroesofageo","tag-significant-reduction","tag-symptoms-of-gastroesophageal-reflux"],"acf":[],"yoast_head":"<!-- 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