{"id":7456,"date":"2026-01-12T09:29:52","date_gmt":"2026-01-12T08:29:52","guid":{"rendered":"https:\/\/www.pjpharma.it\/?p=7456"},"modified":"2026-04-10T09:49:38","modified_gmt":"2026-04-10T08:49:38","slug":"infant-reflux-clinical-study-on-the-efficacy-of-reflucalm","status":"publish","type":"post","link":"https:\/\/www.pjpharma.it\/en\/infant-reflux-clinical-study-on-the-efficacy-of-reflucalm\/","title":{"rendered":"Infant reflux: clinical study on the efficacy of Reflucalm"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>Treatment of reflux in infants: clinical results with Reflucalm<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Gastroesophageal reflux in infants<\/strong>&nbsp;is a common condition characterized by frequent regurgitation, inconsolable crying, sleep disturbances, and feeding difficulties. When persistent, these symptoms can cause significant stress for parents and impact the infant\u2019s overall well-being.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Reflucalm<\/strong>&nbsp;is a medical device specifically designed for the treatment of reflux in newborns. Its&nbsp;<strong>natural, safe, and side effect\u2013free formulation<\/strong>&nbsp;has been evaluated through a&nbsp;<strong>multicenter observational clinical study<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Clinical Study: Methodology and Results in Infants<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The study involved 20 infants treated with Reflucalm for 4 weeks. The efficacy was assessed using the&nbsp;<strong>I-GERQ-R questionnaire<\/strong>&nbsp;(Infant Gastroesophageal Reflux Questionnaire Revised), a validated clinical tool for measuring reflux-related symptoms in infants.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Parameters evaluated included regurgitation, crying, irritability, apnea episodes, and feeding difficulties.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.pjpharma.it\/wp-content\/uploads\/2026\/04\/download-12.webp\"><img decoding=\"async\" src=\"https:\/\/www.pjpharma.it\/wp-content\/uploads\/2026\/04\/download-12-1024x640.webp\" alt=\"\" class=\"wp-image-7454\"\/><\/a><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Clinical Results in Newborns<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">After 4 weeks of treatment, the&nbsp;<strong>average I-GERQ-R score dropped from 24.75 to 9.5<\/strong>, with a mean reduction of&nbsp;<strong>15.25 points<\/strong>&nbsp;(p&lt;0.001). All patients experienced a&nbsp;<strong>\u226550% reduction in symptoms<\/strong>, with notable improvements in behavior, sleep quality, and feeding.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Reflucalm was&nbsp;<strong>well tolerated and safe<\/strong>&nbsp;in all treated infants, making it a&nbsp;<strong>valid and natural solution<\/strong>&nbsp;for managing reflux-related digestive disorders in newborns.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Why Choose Reflucalm for Infants?<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reduces regurgitation and crying<\/li>\n\n\n\n<li>Safe and free from side effects<\/li>\n\n\n\n<li>Improves sleep and appetite<\/li>\n\n\n\n<li>Suitable from birth<\/li>\n<\/ul>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Looking for a B2B-ready or private label solution?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We are certified manufacturers of&nbsp;<strong>medical devices, dietary supplements, and cosmetics<\/strong>.&nbsp;<strong>Reflucalm is ready for market entry or private labeling<\/strong>, with full regulatory and clinical support.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"mailto:info@farmaimpresa.it\"><strong>Contact Us<\/strong><\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Gruppo FarmaImpresa conducted a multicenter observational clinical study to evaluate the effectiveness of Reflucalm, a medical device indicated for the treatment of gastroesophageal reflux in infants. After 4 weeks of treatment, results showed a statistically significant reduction in symptoms assessed using the validated I-GERQ-R questionnaire, with marked improvement in regurgitation, crying, irritability, and feeding difficulties.<\/p>\n","protected":false},"author":2,"featured_media":7457,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[412],"tags":[2118,2120,2119,2069,2054,2121,2125,2123,2122,2124,2092,2126],"class_list":["post-7456","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-studies","tag-clinical-support","tag-gastroesophageal-reflux-in-infants","tag-infant-reflux","tag-manufacturers-of-medical-devices","tag-observational-clinical-study","tag-observational-study","tag-reflusso-gastroesofageo","tag-reflux-in-newborns","tag-sleep-disturbances","tag-sleep-quality","tag-studio-clinico","tag-symptoms-in-infants"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Infant reflux: clinical study on the efficacy of Reflucalm - PJ PHARMA<\/title>\n<meta name=\"description\" content=\"Reflucalm for infants: clinically proven medical device for regurgitation and crying. 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