{"id":3399,"date":"2025-10-03T07:58:56","date_gmt":"2025-10-03T07:58:56","guid":{"rendered":"https:\/\/www.pjpharma.it\/?p=3399"},"modified":"2026-03-23T17:56:10","modified_gmt":"2026-03-23T16:56:10","slug":"cresko-clinical-study-on-supplement-for-asthenic-children","status":"publish","type":"post","link":"https:\/\/www.pjpharma.it\/en\/cresko-clinical-study-on-supplement-for-asthenic-children\/","title":{"rendered":"Cresko: Clinical Study on Supplement for Asthenic Children"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>Psychosocial and Emotional Benefits in Children Aged 3\u201310<\/strong><br><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Childhood asthenia<\/strong> is a growing condition, often underestimated, but capable of significantly affecting the physical, emotional, and cognitive development of children. Persistent fatigue, low energy, difficulty concentrating, and mood changes can signal underlying nutritional deficiencies that, if untreated, may have long-term consequences.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <strong>early years of life<\/strong> represent a critical window for brain and psychosocial development. Between the ages of <strong>3 and 10<\/strong>, children establish the foundation for future intellectual, social, and behavioral abilities. Intervening during this phase with targeted nutritional support can drastically improve not only health outcomes, but also school performance, emotional balance, and social adaptation.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">The Role of Nutrition in Pediatric Development<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Undernutrition<\/strong> in early childhood is directly associated with cognitive delay, poor academic performance, behavioral disorders, and in some cases, future social limitations. Among the most critical micronutrients involved in neurodevelopment is <strong>iron<\/strong>, whose deficiency has been linked to impaired cognition, attention disorders, and fatigue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Other bioactive substances such as <strong>glutamine<\/strong> (involved in gut health and stress response) and <strong>royal jelly<\/strong> (a known adaptogen and tonic) may offer additional support for tired, weak, or emotionally withdrawn children.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Clinical Study on Cresko: Documented Psychosocial Benefits<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">To evaluate the efficacy of a tailored pediatric supplement, <strong>Gruppo FarmaImpresa<\/strong> conducted a <strong>longitudinal observational clinical study<\/strong> on the product <strong>Cresko<\/strong>\u2014a nutritional supplement containing <strong>iron, fresh royal jelly, glutamine, and B vitamins<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study enrolled <strong>71 children<\/strong>, with a mean age of <strong>7.2 \u00b1 2.6 years<\/strong>, treated in three outpatient pediatric centers. Participants received <strong>2 oral vials per day for 30 consecutive days<\/strong>. Clinical effectiveness was assessed using the <strong>aPHQ-9<\/strong>, a validated child-adapted version of the Patient Health Questionnaire 9, specifically designed to evaluate <strong>emotional and psychosocial well-being<\/strong> in pediatric patients.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Study Results: Significant Emotional Improvement<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The results were both statistically and clinically significant:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The <strong>mean aPHQ9 score<\/strong> dropped from <strong>11.5 \u00b1 4.9 to 3.8 \u00b1 4.3<\/strong> after 30 days of supplementation (<strong>p &lt; 0.001<\/strong>), showing a marked reduction in psychological distress and emotional fatigue.<\/li>\n\n\n\n<li><strong>Linear regression analysis<\/strong> showed a positive correlation between improvement and <strong>age (p = 0.004)<\/strong>, <strong>treatment duration (p &lt; 0.001)<\/strong>, and <strong>weight gain (p = 0.002)<\/strong>.<\/li>\n\n\n\n<li>No <strong>short-term adverse events<\/strong> were reported, confirming the supplement\u2019s excellent tolerability and safety profile.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Cresko: A Valid Nutritional Support for Asthenic Children<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Daily oral supplementation with <strong>iron<\/strong>, <strong>fresh royal jelly<\/strong>, and <strong>glutamine<\/strong> over 30 days was proven to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Enhance <strong>emotional resilience<\/strong> and psychosocial well-being<\/li>\n\n\n\n<li>Support <strong>mood balance<\/strong> and school\/social adaptation<\/li>\n\n\n\n<li>Promote <strong>physical and cognitive recovery<\/strong> in asthenic or underperforming children<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">These findings suggest that <strong>Cresko<\/strong> offers a clinically validated solution for pediatricians, caregivers, and healthcare professionals seeking to address fatigue and emotional imbalance in children through <strong>nutraceutical intervention<\/strong>.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Cresko Is Ready for International Distribution<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Cresko<\/strong> is available for <strong>B2B commercialization<\/strong> through:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Private label<\/strong> supply<\/li>\n\n\n\n<li><strong>Out-licensing<\/strong> agreements<\/li>\n\n\n\n<li>Full <strong>technical-regulatory support<\/strong> for international registration<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Backed by a clinical study conducted by <strong>Gruppo FarmaImpresa<\/strong>, Cresko can easily be integrated into your nutraceutical portfolio.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"mailto:info@farmaimpresa.it\">Contact us<\/a><\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Source:Anno VIII, N.2 \u2013 Giugno 2023, Pharmanutrition and Functional Foods.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Psychosocial and Emotional Benefits in Children Aged 3\u201310 Childhood asthenia is a growing condition, often underestimated, but capable of significantly affecting the physical, emotional, and cognitive development of children. Persistent fatigue, low energy, difficulty concentrating, and mood changes can signal underlying nutritional deficiencies that, if untreated, may have long-term consequences. The early years of life&#8230;<\/p>\n","protected":false},"author":3,"featured_media":3402,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[412],"tags":[],"class_list":["post-3399","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-studies"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cresko: Clinical Study on Supplement for Asthenic Children<\/title>\n<meta name=\"description\" content=\"Cresko is a pediatric supplement for asthenic children, clinically shown to improve emotional and psychosocial well-being (aPHQ9). 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