Cresko: Clinical Study on Supplement for Asthenic Children

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Psychosocial and Emotional Benefits in Children Aged 3–10

Childhood asthenia is a growing condition, often underestimated, but capable of significantly affecting the physical, emotional, and cognitive development of children. Persistent fatigue, low energy, difficulty concentrating, and mood changes can signal underlying nutritional deficiencies that, if untreated, may have long-term consequences.

The early years of life represent a critical window for brain and psychosocial development. Between the ages of 3 and 10, children establish the foundation for future intellectual, social, and behavioral abilities. Intervening during this phase with targeted nutritional support can drastically improve not only health outcomes, but also school performance, emotional balance, and social adaptation.


The Role of Nutrition in Pediatric Development

Undernutrition in early childhood is directly associated with cognitive delay, poor academic performance, behavioral disorders, and in some cases, future social limitations. Among the most critical micronutrients involved in neurodevelopment is iron, whose deficiency has been linked to impaired cognition, attention disorders, and fatigue.

Other bioactive substances such as glutamine (involved in gut health and stress response) and royal jelly (a known adaptogen and tonic) may offer additional support for tired, weak, or emotionally withdrawn children.

Clinical Study on Cresko: Documented Psychosocial Benefits

To evaluate the efficacy of a tailored pediatric supplement, Gruppo FarmaImpresa conducted a longitudinal observational clinical study on the product Cresko—a nutritional supplement containing iron, fresh royal jelly, glutamine, and B vitamins.

The study enrolled 71 children, with a mean age of 7.2 ± 2.6 years, treated in three outpatient pediatric centers. Participants received 2 oral vials per day for 30 consecutive days. Clinical effectiveness was assessed using the aPHQ-9, a validated child-adapted version of the Patient Health Questionnaire 9, specifically designed to evaluate emotional and psychosocial well-being in pediatric patients.

Study Results: Significant Emotional Improvement

The results were both statistically and clinically significant:

  • The mean aPHQ9 score dropped from 11.5 ± 4.9 to 3.8 ± 4.3 after 30 days of supplementation (p < 0.001), showing a marked reduction in psychological distress and emotional fatigue.
  • Linear regression analysis showed a positive correlation between improvement and age (p = 0.004), treatment duration (p < 0.001), and weight gain (p = 0.002).
  • No short-term adverse events were reported, confirming the supplement’s excellent tolerability and safety profile.

Cresko: A Valid Nutritional Support for Asthenic Children

Daily oral supplementation with iron, fresh royal jelly, and glutamine over 30 days was proven to:

  • Enhance emotional resilience and psychosocial well-being
  • Support mood balance and school/social adaptation
  • Promote physical and cognitive recovery in asthenic or underperforming children

These findings suggest that Cresko offers a clinically validated solution for pediatricians, caregivers, and healthcare professionals seeking to address fatigue and emotional imbalance in children through nutraceutical intervention.

Cresko Is Ready for International Distribution

Cresko is available for B2B commercialization through:

  • Private label supply
  • Out-licensing agreements
  • Full technical-regulatory support for international registration

Backed by a clinical study conducted by Gruppo FarmaImpresa, Cresko can easily be integrated into your nutraceutical portfolio.

Source:Anno VIII, N.2 – Giugno 2023, Pharmanutrition and Functional Foods.

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